Could the antioxidant Tiron be skin’s fountain of youth?

Researchers have identified an antioxidant called Tiron, which offers total protection against some types of sun damage, and may ultimately help skin stay looking younger for longer.

In The FASEB Journal, the authors described how in laboratory tests, they compared the protection offered against either UVA radiation or free radical stress by several antioxidants, some of which are found in foods or cosmetics.

While UVB radiation easily causes sunburn, UVA radiation penetrates deeper, damaging our DNA by generating free radicals (an atom or molecule that damages cells and/or genetic materials by “stealing” their electrons). This, in turn, degrades the collagen that gives skin its elastic quality.

Could the antioxidant Tiron be skin fountain of youthThe Newcastle University team found that the most potent antioxidants were those that targeted the batteries of the skin cells, known as the mitochondria. They compared these mitochondrial-targeted antioxidants to other non-specific antioxidants such as resveratrol (found in red wine), and curcumin (found in curries), that target the entire cell.

The most potent antioxidant: Tiron

They found that the most potent mitochondrial targeted antioxidant was Tiron, which provided 100 percent protection of the skin cell against UVA sun damage and the release of damaging enzymes causing stress-induced damage. (A 2009 study described Tiron a “ROS [reactive oxygen species] scavenger,” meaning essentially that antioxidants like Tiron neutralize free radicals.)

Author, Mark Birch-Machin, Professor of Molecular Dermatology at Newcastle University said, “To discover that Tiron offers complete protection against UVA damage is exciting and promising; however, it is early days, as Tiron is not a naturally-occurring compound, and has not yet been tested for toxicity in humans.”

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Of the work which, was funded by BBSRC and Unilever, co-author at Newcastle University Dr Anne Oyewole said, “This finding on Tiron provides us with a platform to study an antioxidant — preferably a naturally-occurring compound with a similar structure, which could then be safely added to food or cosmetics.”

Why skin ages

Our skin ages due to the constant exposure to sunlight as ultraviolet radiation from the sun penetrates cells and increases the number of damaging free radicals, especially the reactive oxygen species. Too many reactive oxygen species can be harmful, because they can damage the DNA within our cells.

Over time, this can lead to the accumulation of mutations which speed up ageing and destroy the skin’s supportive fibres, collagen and elastin, causing wrinkles. Recent studies strongly suggest the damage caused by reactive oxygen species may also initiate and exacerbate the development of skin cancers.

Antioxidants in our diets from green tea, resveratrol (which is found in red wine), turmeric (which is used in curries) and lycopene (found in tomatoes), as well as some components in cosmetic creams, are known to neutralize this damage within the cells. They can slow down the damage and the rate of ageing and potentially lower the rate of other sun-induced skin lesions.



Antioxidant Tiron’s protection against DNA damage

The method developed offers the first test which enables the comparison of different antioxidants for their potency in a skin cell based system.

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Skin cells treated with a panel of antioxidants were exposed to a physiological dose of ultraviolet A radiation — that is, the same dose that our skin would normally be exposed to on a warm summer’s day. The DNA within the skin cells was then copied using a polymerase chain reaction machine, in order to assess the amount of DNA damage present.

Using this method, Tiron — a vitamin E analog which has the chemical composition 4,5-Dihydroxy-1,3-benzenedisulfonic acid disodium salt monohydrate — was revealed to provide full protection against mitochondrial DNA damage.

Resveratrol, the antioxidant found in red wine, was found to protect against 22% of both the ultraviolet A radiation and stress-induced damage. NAC, a frequently used laboratory-based anti-oxidant, offered 20% protection against oxidative stress and 8% against UVA, and curcumin offered 16% protection against oxidative stress and 8% against UVA.

In comparison, Tiron offered 100% protection against UVA radiation and 100% protection against oxidative stress.

The team intends to take the work forward by further understanding the mechanism of how Tiron works, developing a compound similar to Tiron and testing for toxicity in humans. They say it will be several years before it is ready for use as a skin product or supplement.



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