How oxytocin makes a mom

Actress Kristen Bell admits that after she first gave birth, she didn’t instantly feel a bond with her baby.

“When Lincoln came out, at first I was like, ‘Eh, what do I do with it? I can take it home?'” Bell told Good Housekeeping in their May 2015 issue. “But when I started breastfeeding, the oxytocin or my hormones or hundreds of thousands of years of evolution kicked in. I didn’t want to let her go.”

Mom and baby - newborn

Hormone teaches mom’s brain to respond to baby’s needs

Neuroscientists at NYU Langone Medical Center have discovered how the powerful brain hormone oxytocin acts on individual brain cells to prompt specific social behaviors — findings that could lead to a better understanding of how oxytocin and other hormones could be used to treat behavioral problems resulting from disease or trauma to the brain.

Until now, researchers say oxytocin — sometimes called the “pleasure hormone” — has been better known for its role in inducing sexual attraction and orgasm, regulating breastfeeding, and promoting maternal-infant bonding. But its precise levers for controlling social behaviors were not known.

“Our findings redefine oxytocin as something completely different from a ‘love drug,’ but more as an amplifier and suppressor of neural signals in the brain,” says study senior investigator Robert Froemke, PhD, an assistant professor at NYU Langone and its Skirball Institute of Biomolecular Medicine.

“We found that oxytocin turns up the volume of social information processed in the brain. This suggests that it could one day be used to treat social anxiety, post-traumatic stress disorder, speech and language disorders, and even psychological issues stemming from child abuse.”

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Mapping oxytocin to unique brain cells to help bonding

In experiments in mice, Dr Froemke and his team mapped oxytocin to unique receptor cells in the left side of the brain’s cortex. They found that the hormone controls the volume of “social information” processed by individual neurons, curbing so-called excitatory or inhibitory signals — and immediately determining how female mice with pups responded to cries for help and attention.

>> Studies expand oxytocin’s role beyond ‘cuddle hormone’

In separate experiments in adult female mice with no pups — and hence no experience with elevated oxytocin levels — adding extra oxytocin into their “virgin” brains led these mice to quickly recognize the barely audible distress calls of another mother’s pups recently removed from their home nest. These adult mice quickly learned to set about fetching the pups, picking them up by the scruffs of their necks and returning them to the nest — all as if they were the pups’ real mother.



This learned behavior was permanent, researchers say; the mice with no offspring continued to retrieve pups even when their oxytocin receptors were later blocked.

According to lead study investigator Bianca Marlin, PhD, a postdoctoral research fellow at NYU Langone, “It was remarkable to watch how adding oxytocin shifted animal behavior, as mice that didn’t know how to perform a social task could suddenly do it perfectly.”

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The findings were published in the journal Nature on April 15, 2015.

Key to the researchers’ efforts to track oxytocin at work in individual brain cells was use of an antibody developed at NYU Langone that specifically binds to oxytocin-receptor proteins on each neuron, allowing the cells to be seen with a microscope.

“Our future research includes further experiments to understand the natural conditions, beyond childbirth, under which oxytocin is released in the brain,” Dr Froemke adds.



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